US Secretary of State Hillary Clinton, right, speaks with French Foreign Minister Laurent Fabius during a meeting , in Paris, Friday July 6, 2012. Syrian opposition leaders are pressing diplomats at an international conference for a no-fly zone over Syria, but the U.S. and its European and Arab partners are expected to focus on economic sanctions instead. (AP Photo/Brendan Smialowski, Pool)
US Secretary of State Hillary Clinton, right, speaks with French Foreign Minister Laurent Fabius during a meeting , in Paris, Friday July 6, 2012. Syrian opposition leaders are pressing diplomats at an international conference for a no-fly zone over Syria, but the U.S. and its European and Arab partners are expected to focus on economic sanctions instead. (AP Photo/Brendan Smialowski, Pool)
US Secretary of State Hillary Clinton, left, walks with French Foreign Minister Laurent Fabius before their meeting in Paris, Friday July 6, 2012. Syrian opposition leaders are pressing diplomats at an international conference for a no-fly zone over Syria, but the U.S. and its European and Arab partners are expected to focus on economic sanctions instead. (AP Photo/Brendan Smialowski, Pool)
French President Francois Hollande, right, shakes hands with the leader of the Syrian National Council (SNC), Abdulbaset Sieda during the Friends of Syria conference, Friday, July 6, 2012 in Paris. The United States and its European partners are threatening new sanctions on Syrian President Bashar Assad's regime if he doesn't act fast on a new peace plan, but the fractured and frustrated Syrian opposition is seeking quick military actions instead. (AP Photo/Patrick Kovarik, Pool)
Former president of Syrian National Council Burhan Ghalioun talk to the media during the "Friends of Syria" conference in Paris, Friday, July 6, 2012. Syrian opposition leaders are pressing diplomats at an international conference for a no-fly zone over Syria, but the U.S. and its European and Arab partners are expected to focus on economic sanctions instead. (AP Photo/Jacques Brinon)
PARIS (AP) ? The United States and its international allies called Friday for new, global sanctions against President Bashar Assad's regime, seeking to step up the pressure after the defection of a top general dealt a major blow to the Syrian leader.
Washington urged countries around the world to demand that Russia and China force Assad to leave power.
Syrian Brig. Gen. Manaf Tlass, a member of the elite Republican Guards and a son of a former defense minister, abandoned Assad's regime, according to Western officials. It was the highest profile departure in 16 months of brutal government crackdowns and civil war that activists say has killed more than 14,000 people.
French Foreign Minister Laurent Fabius said Tlass had defected and was en route to France, where he has a sister and where world diplomats met Friday to bolster the Syrian opposition. Later, Fabius backtracked, saying he was not sure of Tlass' final destination.
A member of Syria's opposition National Council, Hassem Hashimi, described Tlass as a powerful figure in the Assad regime.
"The defection of Tlass will encourage a lot of similar people to defect as well," he told The Associated Press in Paris.
U.S. Secretary of State Hillary Rodham Clinton joined senior officials from about 100 other countries in Paris to win wider support for a Syrian transition plan unveiled last week by U.N. mediator Kofi Annan. Joined by America's allies, she called for "real and immediate consequences for non-compliance, including sanctions," against the Assad regime.
But with neither Moscow nor Beijing in attendance, much remained dependent on persuading the two reluctant U.N. veto-wielding powers to force Assad into abiding by a cease-fire and the transition strategy. Clinton urged governments around the world to direct their pressure toward Russia and China as well.
"What can every nation and group represented here do?" Clinton asked. "I ask you to reach out to Russia and China, and to not only urge but demand that they get off the sidelines and begin to support the legitimate aspirations of the Syrian people."
"I don't think Russia and China believe they are paying any price at all ? nothing at all ? for standing up on behalf of the Assad regime," she added. "The only way that will change is if every nation represented here directly and urgently makes it clear that Russia and China will pay a price. Because they are holding up progress, blockading it. That is no longer tolerable."
Britain's foreign secretary, William Hague, said, "We don't rule out any option for the future because it is deteriorating. It is a very grave situation. It is a murdering regime, so we want to see a peaceful transition. But we are not ruling anything out."
Diplomats urged the Syrian opposition to unite.
Syria's fractured opposition is seeking quick military support. Hashimi called for a no-fly zone to prevent military forces from "flying over defected soldiers and civilians and bombarding them."
"We're sick of meetings and deadlines. We want action on the ground," said activist Osama Kayal, speaking via Skype from an area near in the northern Syrian city of Khan Sheikhoun, which has been under Syrian army fire for days..
In Paris, Burhan Ghalioun, former leader of the Syrian National Council, explain his frustration after the conference.
"I am not satisfied at all because the Syrians are not waiting for press communiques. What preoccupies the Syrians today is the way we can stop the massacre. Every day there are 100, 130, 150 victims and the people only think about that," he said. "They want action, they want measures and practical mechanism to stop the killings."
But military intervention is not on the immediate horizon. U.S. officials say they are focusing on economic pressure, and the Obama administration says it won't intervene militarily or provide weapons to the Syrian rebels for what it considers to be an already too-militarized conflict.
Any international mandate for military intervention would almost certainly be blocked by Russia and Moscow in the U.N. Security Council.
U.S. officials say a U.N. resolution could be introduced next week, but one that only seeks further economic pressure on Assad's government. Even the chances for that action are unclear, with Russia and China effectively watering down Annan's blueprint for transition at a conference in Geneva last weekend. That plan granted both Assad and the opposition veto over any interim government candidate they oppose.
Tlass was one of the most important Sunni figures in Syria's Alawite-dominated regime.
As the son of longtime Defense Minister Mustafa Tlass, he was a member of the Syrian Baath Party aristocracy, part of a privileged class that flourished under the Assad dynasty.
His father and Assad's father, Hafez, had been close friends since their days in the Syrian military academy in Homs and became even closer after being posted to Cairo in the late 1950s when Egypt and Syria merged into the United Arab Republic ? a union that lasted three years. After Hafez Assad rose to power in the early 1970s, Mustafa Tlass became defense minister and the Syrian president's most trusted lieutenant.
When Hafez died of a heart attack in 2000, Tlass helped engineer Bashar's succession to the presidency and guided the inexperienced young doctor. Tlass was the leader of a coterie of old regime figures that critics blamed for reining in moves to liberalize the Syrian regime.
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Catherine Gaschka in Paris, Robert H. Reid in Berlin and Ben Hubbard in Beirut contributed to this report.
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