Thursday, 31 May 2012

King's Automotive in Saint Louis, Missouri Adds U-Haul Rentals

ST. LOUIS, May 30, 2012 /PRNewswire/ --? Vincent King, owner of King's Automotive, located at 235 Chambers Rd., recently added U-Haul truck and trailer rentals to the auto-repair business.

(Logo: http://photos.prnewswire.com/prnh/20090622/LA34860LOGO-b)

Click here to download the photo accompanying this press release.

Families needing the finest in moving services now will have increased convenience and a shorter distance to travel when moving, which not only will make their move easier but also will have the positive effect of reducing the amount of carbon emissions released into the atmosphere. U-Haul partnering with business owners across North America to increase convenience for customers while helping our environment is just one of the programs that support U-Haul Company's Corporate Sustainability initiatives.

King's Automotive can now offer its customers a variety of moving equipment and supplies designed specifically for moving household furnishings, including moving vans, open trailers, closed trailers, furniture pads, appliance dollies, furniture dollies, tow dollies and auto transports. King's Automotive also will offer sales items to protect their customers' belongings and make moving easier, such as heavy-duty boxes, which are made of up to 90 percent recycled content and are available in a variety of sizes.

"U-Haul is proud to be partnering with a quality independent business such as King's Automotive," exclaimed Stephen Langford, president, U-Haul Company of Saint Louis. "Vincent is a great example of the type of successful business relationship U-Haul has established in order to build and maintain a strong network of more than 15,000 independent dealers across North America."

Learn more about Missouri: http://www.uhaul.com/SuperGraphics/264/Venture-Across-America-and-Canada-Modern/Missouri! ?

For more information, or to rent your moving equipment today, call (314) 400-2785. Business hours of operation are: Mon. ? Fri. 8 a.m. ? 5:30 p.m. and Sat. 7 a.m. ? 11 p.m.

About U-Haul
U-Haul was founded by a Navy veteran who grew up during the Great Depression. Tires and gas were still rationed or in short supply during the late 1940s when U-Haul began serving U.S. customers. Today, that background is central to the U-Haul Sustainability Program: "Serving the needs of the present without compromising the ability of future generations to meet their own needs."? Our commitment to reduce, reuse and recycle includes fuel-efficient moving vans, neighborhood proximity, moving box reuse, moving pads made from discarded material and packing peanuts that are 100% biodegradable.? Learn more about these facts and others at uhaul.com/sustainability.

Since 1945, U-Haul has been the choice for the do-it-yourself mover. U-Haul customers' patronage has enabled the Company to maintain the largest rental fleet in the do-it-yourself moving industry which includes trucks, trailers and towing devices. U-Haul also offers storage throughout North America. The Company provides industry leading moving and storage boxes and an extended line of packing supplies to protect customer possessions. U-Haul is the consumer's number one choice as the largest installer of permanent trailer hitches in the automotive aftermarket. The Company supplies alternative-fuel for vehicles and backyard grills as one of the nation's largest retailers of propane.

Contact:
Joanne Fried
Kelie Hale
U-Haul Public Relations
(602) 263-6194
(602) 263-6772 fax

SOURCE U-Haul

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Vanilla Ice Hints At 'Ninja Turtles' Involvement

'I'd be all over that,' the rapper told MTV News about the upcoming 'Turtles' reboot.
By Josh Wigler, with reporting by Jim Cantiello


Vanilla Ice
Photo: MTV News

There's a lot happening within the "Teenage Mutant Ninja Turtles" universe that's rubbed fans the wrong way. Chief among their grievances is a change to the Turtles' origin: These heroes in a half-shell are no longer simply the mutated product of an ooze spill on some unwitting turtles — they're now creatures from a different planet.

But there's at least one carryover from the original film trilogy that should put a smile on fans' faces: Vanilla Ice is back, back, baby ... maybe.

MTV News caught up with the rapper during his Sneak Peek Week appearance for "That's My Boy" ahead of Sunday night's MTV Movie Awards, and he teased that he may very well be involved with the Michael Bay-produced "Ninja Turtles" reboot.

"I can't say anything," Ice grinned when asked if he would be involved with the return of the Turtles. "I know that they're not from the sewers now. They're aliens now or something."

Ice, who famously performed "Ninja Rap" in "Teenage Mutant Ninja Turtles II: The Secret of the Ooze," is a committed fan of Splinter's reptilian warriors. Like, seriously committed, to the extent that he's tattooed their likeness to his own shin.

"I don't mess around," he said of his "TMNT" pride. "I'm still a Ninja Turtles fan."

And to that end, Ice said he's very much interested in continuing his relationship with the fan-favorite franchise. Whether or not he's actually involved with Bay's planned reboot remains a mystery for now, but the rapper is wide open to the possibility at the very least.

"Absolutely," he said when asked if he'd want to join in on the new-age "Turtles" fun. "I'd get a tattoo of it. I'd be all over that. Aliens, sewers, whatever: They're still Ninja Turtles, and I'm a ninja, so I get in where I fit in."

Head over to MovieAwards.MTV.com to vote for your favorite flicks now! The 21st annual MTV Movie Awards air live this Sunday, June 3, at 9 p.m.

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Faces Of Skin Cancer

(Family Features) Summer is here, which means swimming, picnics and barbecues. These warmer days encourage many people to go outside and enjoy the sunshine. However, many are unaware of the serious consequences that can develop from sun exposure, including advanced skin cancer.

An estimated one in five Americans will develop some form of skin cancer in their lifetime. Most cases can be cured if caught early and treated when the disease is restricted to a small area. However, in some instances the cancer may come back or spread to other parts of the body. When skin cancer becomes advanced, the disease can be debilitating and, in some cases, may even become deadly.

A diagnosis at this advanced stage can be devastating. According to a recent online survey of people affected by advanced skin cancer, *people diagnosed with this disease often feel scared, overwhelmed and isolated.

However, a new online resource called Faces of Skin Cancer provides resources that can help. The program offers people with advanced skin cancer and their caregivers an opportunity to hear from others and share their experiences with those who?ve been affected.

Faces of Skin Cancer aims to make a difference in the lives of those affected by advanced skin cancer by offering a platform for sharing stories.

The website features stories of people affected by advanced skin cancer and their experiences, including ways they have coped with this disease. The website also allows for visitors to share their own stories about advanced skin cancer. For each story submitted, $1 will be donated to advanced skin cancer programs.

To learn more about the lives of those affected by advanced skin cancer, please visit www.facesofskincancer.org and view the Faces of Skin Cancer video. One dollar will be donated to advanced skin cancer programs for each video view.

Remember, it is always important to be mindful of the sun?s harmful rays even when the sun is not out. Skin should be protected by wearing tightly woven clothing and a wide-brimmed hat, applying sunscreen that has a sun protection factor (SPF) of 15 or higher and seeking shade.

*Survey of 238 respondents was conducted in March 2012 on behalf of Genentech, The Skin Cancer Foundation and Melanoma Research Foundation.

Did You Know?

  • More than 65 percent of those with advanced skin cancer did not know what advanced skin cancer was at diagnosis.
  • Those polled said the best resources were from their doctor and online.
  • More than 75 percent don?t believe or aren?t sure there is enough information available about advanced skin cancer.
Photo courtesy of Getty Images

SOURCE:
Genentech

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Game Fire - Gaming Performance Boost on Windows

Game Fire - Gaming Performance Boost on Windows -Games like Battlefield 3, Crysis 2 and Skytrim desperately need video capabilities and computer system are high. How to solve our computer performance when you want to play cool games that is a trend now? Do we have to buy a new computer with high tech spec? Or to upgrade the RAM, VGA and motherboard on our old computer?

It seems that which we must do to follow pace of the game world, but what if it had not yet overcome our problems. Let's say our computers still lag while playing the game. To solve this problem you can use Game Fire.

Game Fire is software to boost the performance of the performance of windows, in other words to optimize Game Fire in the Windows system and help you when playing games with HD quality.

How does the performance of Game Fire? When you activate the?Game Fire, then Game Fire will overcome the performance of windows with a cover system that is not needed when we would play games, so the RAM usage will be reduced.

So if you want to have a fast computer while playing?

1. Game Fire Download:
http://www.smartpcutilities.com/gamefire.html
System Requirements:
- Microsoft(R) Windows(TM) Vista (32-bit and 64-bit) Starter/Home Basic/Home Premium/Business /Ultimate
- Microsoft(R) Windows(TM) 7 (32-bit and 64-bit) Starter/Home Basic/Home Premium/Professional/Ultimate
- Microsoft(R) Windows(TM) XP (32-bit and 64-bit) Home/Professional/Media Center
- Microsoft .NET Framework 4 Client Profile.
Hardware Requirements:
- 256 MB of RAM.
- 800 MHz processor or faster processor.
- 10 MB of free hard disk space.
2. After the download is complete, immediately install the Game Fire in the computer.

Game Fire is an open source software: you can redistribute it and/or modify it under the terms of the GNU General Public License.

You should know about Game Fire are:
You can turn on Game Mode when you want to play games and you can disable it to normal mode when not playing games.

At the time of first use Game Fire, you will be prompted to configure the performance of Game Fire.

Game Fire also provide a report every time turned on and off. The report contains a summary of the discontinued use of the application and activated. in addition, the report can also be formed into HTML format.

Game Fire Setting on the menu there are three settings available and you may modify: General, Live Gaming Mode and My Game.

What do you think about this Game Fire? You can speed up your computer with just one click instead? If this article useful and help you, click the like, tweet or plus one. Do not forget to share as well, perhaps you need a friend or a friend this article :).

Hey don't forget about?Free download Iobit Game Booster until now and June 30th

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Wednesday, 30 May 2012

Romney clinches GOP nomination with Texas win

Republican presidential candidate, former Massachusetts Gov. Mitt Romney greets a group of veterans after speaking at a campaign event, Tuesday, May 29, 2012, in Craig, Colo. (AP Photo/Mary Altaffer)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney greets a group of veterans after speaking at a campaign event, Tuesday, May 29, 2012, in Craig, Colo. (AP Photo/Mary Altaffer)

FILE - In this May 23, 2012 file photo, Republican presidential candidate former Massachusetts Gov. Mitt Romney speaks in Washington. Romney is set to clinch the Republican nomination for president Tuesday with a win in the Texas primary, a feat of endurance for a candidate who came up short four years ago and watched this year as voters flirted with a carousel of front-runners before eventually warming to him. (AP Photo/Mary Altaffer, File)

FILE - In this Feb. 2, 2012 file photo, Donald Trump greets Republican presidential candidate, former Massachusetts Gov. Mitt Romney during a news conference in Las Vegas. Romney is set to clinch the Republican nomination for president Tuesday with a win in the Texas primary, a feat of endurance for a candidate who came up short four years ago and watched this year as voters flirted with a carousel of front-runners before eventually warming to him. (AP Photo/Julie Jacobson, File)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks in Craig, Colo., Tuesday, May 29, 2012. (AP Photo/Mary Altaffer)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney holds a baby as he greets supporters after speaking at a campaign event, Tuesday, May 29, 2012, in Craig, Colo. (AP Photo/Mary Altaffer)

(AP) ? Mitt Romney clinched the Republican presidential nomination Tuesday with a win in the Texas primary, a triumph of endurance for a candidate who came up short four years ago and had to fight hard this year as voters flirted with a carousel of GOP rivals.

According to The Associated Press count, Romney surpassed the 1,144 delegates needed to win the nomination by winning at least 97 delegates in the Texas primary.

The former Massachusetts governor has reached the nomination milestone with a steady message of concern about the U.S. economy, a campaign organization that dwarfed those of his GOP foes and a fundraising operation second only to that of his Democratic opponent in the general election, President Barack Obama.

Romney would be the first Mormon nominated by a major party. His religion has been less of an issue than it was during his failed bid four years ago.

"We did it!" Romney proclaimed in a message to supporters, noting that "it's only the beginning."

"An honor and a privilege and a great responsibility," Romney told supporters at a fundraiser in Las Vegas. "And I know the road to 1,144 was long and hard, but I also know that the road to 11-06 ? Nov. 6th ? is also going to be long and it's going to be hard and it's going to be worth it because we're going to take back the White House and get America right again."

Romney must now fire up conservatives who still doubt him while persuading swing voters that he can do a better job fixing the nation's struggling economy than Obama. In Obama, he faces a well-funded candidate with a proven campaign team in an election that will be heavily influenced by the economy.

Romney's campaign went on the attack Tuesday, releasing a Web video citing the Obama administration's loan-guarantee investments in four renewable-energy firms that lost money and laid off workers.

The message ? "President Obama is fundamentally hostile to job creators" ? has been a theme of the Romney campaign since he launched his presidential bid. But sensing an opportunity to reach a new audience, the campaign planned to highlight Obama's support for the failed renewable energy company Solyndra, among other private ventures the Obama administration helped support.

"We need to have presidents who understand how this economy works," Romney told reporters Tuesday. "Sometimes I just don't think he understands what it takes to help people. I know he wants to help, but he doesn't know what he's got to do."

Romney's message and his big day, however, were somewhat overshadowed by real estate mogul Donald Trump and his discredited suggestions that Obama wasn't born in the United States.

Romney spent Tuesday evening at a Las Vegas fundraiser with Trump, who had toyed with the idea of running for president. Romney says he believes Obama was born in America but has yet to condemn Trump's repeated insinuations to the contrary.

"If Mitt Romney lacks the backbone to stand up to a charlatan like Donald Trump because he's so concerned about lining his campaign's pockets, what does that say about the kind of president he would be?" Obama's deputy campaign manager, Stephanie Cutter, said in a statement.

Both Trump and Romney steered clear of the issue at Tuesday's fundraiser. Asked Monday about Trump's contentions, Romney said: "I don't agree with all the people who support me. And my guess is they don't all agree with everything I believe in." He added: "But I need to get 50.1 percent or more. And I'm appreciative to have the help of a lot of good people."

Republicans won't officially nominate Romney until late August at the GOP national convention in Tampa, Fla. Romney has 1,183 convention delegates.

He won at least 97 delegates in Texas with 33 left to be decided. The 152 delegates in Texas are awarded in proportion to the statewide vote. The other delegates were sprinkled among several candidates.

Texas Republicans also voted in a Senate primary to choose a candidate to run for the seat being vacated by Sen. Kay Bailey Hutchison. Lt. Gov. David Dewhurst and state Solicitor General Ted Cruz were headed to a runoff in July.

With about three-fourths of precincts reporting, Dewhurst led with 45 percent of the vote compared to 33 percent for Cruz. Dewhurst, however, fell short of the majority he needed to avoid a runoff. The nominee will be strongly favored to win in November in heavily Republican Texas.

Romney, 65, is clinching the presidential nomination later in the calendar than any recent Republican candidate ? but not quite as late as Obama in 2008. Obama clinched the Democratic nomination on June 3, 2008, at the end of an epic primary battle with Hillary Rodham Clinton. Four years ago, John McCain reached the threshold on March 4, after Romney had dropped out of the race about a month earlier.

This year's primary fight was extended by a back-loaded primary calendar, new GOP rules that generally awarded fewer delegates for winning a state and a Republican electorate that built up several other candidates before settling on Romney.

Rick Perry, Herman Cain, Newt Gingrich, Rick Santorum and Trump ? all of them sat atop the Republican field at some point. Minnesota Rep. Michelle Bachmann peaked for a short time, too. But Romney outlasted them all, even as some GOP voters and tea party backers questioned his conservative credentials.

The primary race started in January with Santorum, the former Pennsylvania senator, narrowly edging Romney in the Iowa caucuses. Romney rebounded with a big win in New Hampshire before Gingrich, the former House speaker, won South Carolina.

Romney responded with a barrage of negative ads against Gingrich in Florida and got a much-needed 14-point win. Romney's opponents fought back: Gingrich called him a liar, and Santorum said Romney was "the worst Republican in the country" to run against Obama.

Gingrich and Santorum assailed Romney's work at Bain Capital, the private equity firm he co-founded, saying the firm sometimes made millions at the expense of workers and jobs. It is a line of attack that Obama has promised to carry all the way to November.

On Feb. 7 Santorum swept all three contests in Missouri, Colorado and Minnesota, raising questions about Romney's status as the front-runner. After a 17-day break in the voting, Romney responded with wins in Arizona, Michigan and Washington state before essentially locking up the nomination on March 6, this year's version of Super Tuesday.

Romney has been in general-election mode for weeks, raising money and focusing on Obama, largely ignoring the primaries since his competitors dropped out or stopped campaigning. Santorum suspended his campaign April 10, and Gingrich left the race a few weeks later.

Both initially offered tepid endorsements of Romney but Gingrich is now actively promoting Romney's campaign.

Texas Rep. Ron Paul said on May 14 he would no longer compete in primaries, though his supporters are still working to gain national delegates at state conventions.

Rich Galen, a Republican strategist who has been unaligned in the 2012 race, said the long, sometimes nasty primary fight should help Romney fine-tune his campaign organization so it can operate effectively in the general election. Galen doesn't, however, think it was relevant in toughening up Romney for the battle against Obama.

"Romney's been running for president for six years. He is as good a candidate as he's ever going to be," Galen said. "Whatever you say about him, he was better than everybody else in the race."

___

Associated Press writer Steve Peoples contributed to this report from Las Vegas.

Associated Press

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Judges sentence Charles Taylor to 50 years

Former Liberian President Charles Taylor waits for the start of his sentencing judgement in the courtroom of the Special Court for Sierra Leone(SCSL) in Leidschendam, near The Hague, Netherlands, Wednesday May 30, 2012. The SCSL found Taylor guilty last month on 11 charges of aiding and abetting the rebels who went on a bloody rampage during the decade-long war that ended in 2002 with more than 50,000 dead. Taylor became the first former head of state convicted by an international war crimes court since World War II. Taylor will serve his sentence in a British prison. (AP Photo/Toussaint Kluiters, Pool)

Former Liberian President Charles Taylor waits for the start of his sentencing judgement in the courtroom of the Special Court for Sierra Leone(SCSL) in Leidschendam, near The Hague, Netherlands, Wednesday May 30, 2012. The SCSL found Taylor guilty last month on 11 charges of aiding and abetting the rebels who went on a bloody rampage during the decade-long war that ended in 2002 with more than 50,000 dead. Taylor became the first former head of state convicted by an international war crimes court since World War II. Taylor will serve his sentence in a British prison. (AP Photo/Toussaint Kluiters, Pool)

Former Liberian President Charles Taylor waits for the start of his sentencing judgement in the courtroom of the Special Court for Sierra Leone (SCSL) in Leidschendam, near The Hague, Netherlands, Wednesday May 30, 2012. The SCSL found Taylor guilty last month on 11 charges of aiding and abetting the rebels who went on a bloody rampage during the decade-long war that ended in 2002 with more than 50,000 dead. Taylor became the first former head of state convicted by an international war crimes court since World War II. Taylor will serve his sentence in a British prison. (AP Photo/Toussaint Kluiters, Pool)

Former Liberian President Charles Taylor waits for the start of his sentencing judgement in the courtroom of the Special Court for Sierra Leone(SCSL) in Leidschendam, near The Hague, Netherlands, Wednesday May 30, 2012. The SCSL found Taylor guilty last month on 11 charges of aiding and abetting the rebels who went on a bloody rampage during the decade-long war that ended in 2002 with more than 50,000 dead. Taylor became the first former head of state convicted by an international war crimes court since World War II. Taylor will serve his sentence in a British prison. (AP Photo/Toussaint Kluiters, Pool)

(AP) ? Former Liberian President Charles Taylor was sentenced to 50 years imprisonment Wednesday for arming and supporting murderous rebels in Sierra Leone in return for "blood diamonds," a landmark sentence activists hope will send a clear message to despots around the world that they will be held to account for sponsoring atrocities.

Taylor, wearing a blue suit and gold tie, stood grim-faced and silent as Presiding Judge Richard Lussick of Samoa imposed what will likely amount to a life sentence for the 64 year old.

Lussick said Taylor's position as head of state at the time of his crimes put him in a "class of his own" when judges came to setting the sentence ? one of the longest ever handed down by the Special Court for Sierra Leone or any other international tribunal.

Taylor shipped arms, ammunition and other supplies to rebels in Sierra Leone in return for personal wealth in the form of diamonds mined by slave labor and to gain increasing political clout in the volatile West Africa region.

Taylor's reaction in court Wednesday was in stark contrast to the delight of survivors who gathered in the Sierra Leone capital, Freetown, to watch a live feed of the sentencing .

"That makes me the happiest person on earth," said Alimami Kanu, who was 11 when rebels backed by Taylor hacked off his right hand. He was one of thousands of civilians mutilated during Sierra Leone's decade-long civil war that ended in 2002 with some 50,000 dead.

Human rights activists and international law experts also hailed the tough sentence as a warning shot for war criminals.

"Today's sentence not only reflects the severity of Taylor's crimes but sends a clear message that individuals who aid and abet war crimes can no longer act with impunity," said Patrick Alley, director of Global Witness, a nongovernment group that campaigns to prevent conflicts erupting around exploitation of natural resources such as diamonds and timber.

The sentence came a month after Taylor became the first former head of state since World War II to be convicted by an international court. Judges found him guilty of 11 counts of war crimes and crimes against humanity, including murder, rape, torture and the use of child soldiers.

"The lives of many more innocent civilians in Sierra Leone were lost or destroyed as a direct result of his actions," Lussick said.

Prosecutors had sought an 80-year sentence and said they are considering appealing.

"It is important in our view that those responsible for criminal misconduct on a massive scale are not given a volume discount," said the U.N.-backed court's chief prosecutor, Brenda Hollis.

Hollis said Taylor's prison term would only provide a measure of closure for victims of one of Africa's most savage conflicts.

"The sentence that was imposed today does not replace amputated limbs. It does not bring back those who were murdered," she said. "It does not heal the wounds of those who were victims of sexual violence and does not remove the permanent emotional and psychological and physical scars of those enslaved or recruited as child soldiers."

Taylor will serve his sentence in a British jail. His lawyers, however, said they will appeal his convictions and that will likely keep him in a jail in The Hague, Netherlands, for months.

Taylor's lead attorney, Courtenay Griffiths, criticized the court for refusing while setting Taylor's sentence to take into account his decision to step down from power following his indictment in 2003. Griffiths said that sends a worrying message against the backdrop of ongoing atrocities allegedly being committed by Syrian President Bashar Assad's forces.

"What lesson does that send to President Assad?" Griffiths said. "Maybe the lesson is: If you are a sitting leader and the international community wants to get rid of you, either you get murdered like Col. Gadhafi, or you hang on until the bitter end. I'm not so sure that's the signal this court ought to be transmitting at this particular historical juncture."

Griffiths said Africans should use Taylor's conviction as a starting point to campaign for justice for themselves.

"Justice isn't something which Africans should obtain, exported to them from abroad by the white man, the civilizing force," he said.

His comments appeared to be aimed not only at Taylor's trial, but also at the world's first permanent war crimes tribunal, the International Criminal Court, which has been in operation for 10 years and has so far launched prosecutions only in Africa, including in Sudan, Congo, Libya and Ivory Coast.

At a sentencing hearing earlier this month, Taylor expressed "deepest sympathy" for the suffering of victims of atrocities in Sierra Leone, but insisted he had acted to help stabilize the West Africa region and claimed he never knowingly assisted in the commission of crimes.

Judges rejected that argument, saying that while he posed as a peacemaker he was covertly fanning the flames of conflict by arming rebels.

Taylor stepped down and fled into exile in Nigeria after being indicted by the court in 2003. He was finally arrested and sent to the Netherlands in 2006.

While the Sierra Leone court is based in that country's capital, Freetown, Taylor's trial is being staged in Leidschendam, a suburb of The Hague, for fear holding it in West Africa could destabilize the region.

Mark Ellis, the executive director of legal group The International Bar Association, said the verdict and sentence should act as a deterrent ? in time.

"So far in the recent history of these courts doesn't suggest that these courts are a deterrent yet. But that is the hope that eventually they will be," he said.

____

Andrew Drake and Clarence Roy-Macaulay in Freetown, Sierra Leone, contributed.

Associated Press

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Tuesday, 29 May 2012

Why chemotherapy fails

Why chemotherapy fails [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science

Research led by Weizmann Institute scientists show why leukemia often returns

The fight against cancer is not won in a single battle: Long after a cancer has been beaten into remission, it can return. The reason for this is under debate, and much is unclear. New research led by Weizmann Institute scientists shows that, at least for one type of blood cancer, the source of cancer recurrence is in a set of cells that do not proliferate as quickly as regular cancer cells, and thus able to survive chemotherapy. The findings, which appeared today in the journal Blood, have some important implications for the future of the war on cancer.

Cancer involves a breakdown in the mechanism that regulates the pace of cell division. When this happens, cells divide rapidly, leading to unchecked growth that overruns the body. The most common chemotherapy drugs are those which specifically attack cells that are undergoing rapid division, and these, indeed, often destroy all the cancer and cure the patient.

But there are also quite a few leukemia patients who go through chemotherapy only to have the cancer return. Why does this happen? Several explanations have been proposed. One is that the chemotherapy does not kill every last cancer cell, leaving a few to continue dividing out of control until the disease returns in full force. A second explanation proposes that chemotherapy does get all the regular cancer cells, but there is another type of cancer cell that hides in the body. As opposed to the rapidly dividing majority of cancer cells, these undergo slow division, enabling them to evade the chemotherapy drugs. These insidious cells can give rise to new rapidly-dividing cancer cells, which is why they are known as "cancer stem cells."

Which explanation is correct? The debate is an important one because, if the first explanation holds true, improving upon the existing treatments might help, while the second implies that a completely different approach to treatment will be needed to root out the slowly dividing cancer stem cells.

To attempt to resolve that debate, the team of Prof. Ehud Shapiro of the Weizmann Institute's Biological Chemistry, and Applied Mathematics and Computer Sciences Departments, worked with scientists and physicians from Rambam Medical Center and the Technion, both in Haifa. They used a method of reconstructing cell lineage trees that has been developed over the past few years in Shapiro's lab. This method is based on the fact that the genetic material in different body cells accumulates unique mutations during cell division, and these mutations are passed on to daughter cells during cell division. By comparing mutations, one can map out cells' detailed family trees, and thus determine how far back they share a common ancestor. The end product of this analysis is a tree that reconstructs the genealogy of the cells from their earliest forebears at the base of the tree to the youngest cells at the tips of the branches.

To reconstruct the cancer cell lineage tree, the team used two sets of blood samples: the first taken from leukemia patients right after the disease was diagnosed, and the second from those patients who had undergone chemotherapy and in whom the cancer had returned. The researchers could then trace the relationships of the recurring cancer cells back to see if they descended from the original cancer cells. The lineage tree showed that, at least in some of the patients, the source of the renewed cancer was not in the rapidly proliferating cancer cells, but rather in cells that were close to the root of the tree. These cells had only divided a few times. In other words, the cancer arose from cells that divide very slowly, making them resistant to the attacks of chemotherapy drugs.

Shapiro: "We know that in many cases, chemotherapy alone is not able to cure leukemia. Our results suggest that to completely eliminate it, we must look for a treatment that will not only eliminate the rapidly dividing cells, but also target the cancer stem cells that are resistant to conventional treatment."

###

Participating in the research were Dr. Liran Shlush of the Technion's Rappaport Faculty of Medicine and Rambam Medical Center; Noa Chapal-Ilani and Dr. Rivka Adar of the Weizmann Institute; Profs. Karl Skorecki and Jacob Rowe of the Technion; Dr. Tsila Zuckerman of Rambam and the Technion; and additional investigators.

Prof. Ehud Shapiro's research is supported by the Paul Sparr Foundation; Miel de Botton, UK. The Carolito Stiftung; and the European Research Council. Prof. Shapiro is the incumbent of the Harry Weinrebe Professorial Chair of Computer Science and Biology. His research is also supported by an ERC Advanced Grant.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il/, and are also available at http://www.eurekalert.org/


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Why chemotherapy fails [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science

Research led by Weizmann Institute scientists show why leukemia often returns

The fight against cancer is not won in a single battle: Long after a cancer has been beaten into remission, it can return. The reason for this is under debate, and much is unclear. New research led by Weizmann Institute scientists shows that, at least for one type of blood cancer, the source of cancer recurrence is in a set of cells that do not proliferate as quickly as regular cancer cells, and thus able to survive chemotherapy. The findings, which appeared today in the journal Blood, have some important implications for the future of the war on cancer.

Cancer involves a breakdown in the mechanism that regulates the pace of cell division. When this happens, cells divide rapidly, leading to unchecked growth that overruns the body. The most common chemotherapy drugs are those which specifically attack cells that are undergoing rapid division, and these, indeed, often destroy all the cancer and cure the patient.

But there are also quite a few leukemia patients who go through chemotherapy only to have the cancer return. Why does this happen? Several explanations have been proposed. One is that the chemotherapy does not kill every last cancer cell, leaving a few to continue dividing out of control until the disease returns in full force. A second explanation proposes that chemotherapy does get all the regular cancer cells, but there is another type of cancer cell that hides in the body. As opposed to the rapidly dividing majority of cancer cells, these undergo slow division, enabling them to evade the chemotherapy drugs. These insidious cells can give rise to new rapidly-dividing cancer cells, which is why they are known as "cancer stem cells."

Which explanation is correct? The debate is an important one because, if the first explanation holds true, improving upon the existing treatments might help, while the second implies that a completely different approach to treatment will be needed to root out the slowly dividing cancer stem cells.

To attempt to resolve that debate, the team of Prof. Ehud Shapiro of the Weizmann Institute's Biological Chemistry, and Applied Mathematics and Computer Sciences Departments, worked with scientists and physicians from Rambam Medical Center and the Technion, both in Haifa. They used a method of reconstructing cell lineage trees that has been developed over the past few years in Shapiro's lab. This method is based on the fact that the genetic material in different body cells accumulates unique mutations during cell division, and these mutations are passed on to daughter cells during cell division. By comparing mutations, one can map out cells' detailed family trees, and thus determine how far back they share a common ancestor. The end product of this analysis is a tree that reconstructs the genealogy of the cells from their earliest forebears at the base of the tree to the youngest cells at the tips of the branches.

To reconstruct the cancer cell lineage tree, the team used two sets of blood samples: the first taken from leukemia patients right after the disease was diagnosed, and the second from those patients who had undergone chemotherapy and in whom the cancer had returned. The researchers could then trace the relationships of the recurring cancer cells back to see if they descended from the original cancer cells. The lineage tree showed that, at least in some of the patients, the source of the renewed cancer was not in the rapidly proliferating cancer cells, but rather in cells that were close to the root of the tree. These cells had only divided a few times. In other words, the cancer arose from cells that divide very slowly, making them resistant to the attacks of chemotherapy drugs.

Shapiro: "We know that in many cases, chemotherapy alone is not able to cure leukemia. Our results suggest that to completely eliminate it, we must look for a treatment that will not only eliminate the rapidly dividing cells, but also target the cancer stem cells that are resistant to conventional treatment."

###

Participating in the research were Dr. Liran Shlush of the Technion's Rappaport Faculty of Medicine and Rambam Medical Center; Noa Chapal-Ilani and Dr. Rivka Adar of the Weizmann Institute; Profs. Karl Skorecki and Jacob Rowe of the Technion; Dr. Tsila Zuckerman of Rambam and the Technion; and additional investigators.

Prof. Ehud Shapiro's research is supported by the Paul Sparr Foundation; Miel de Botton, UK. The Carolito Stiftung; and the European Research Council. Prof. Shapiro is the incumbent of the Harry Weinrebe Professorial Chair of Computer Science and Biology. His research is also supported by an ERC Advanced Grant.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,700 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il/, and are also available at http://www.eurekalert.org/


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How to Avoid Nutritional Intake Decreased

People are now advocating nutrition and health, so they focus on the daily nutritional intake. But how can they intake of adequate nutrition?

I think they should eat a variety of fruits and vegetables: guarantee to have two kinds of vegetables a meal, and eat 2 to 3 kinds of fruit a day, eat fruits and vegetables as much as possible within a week. The different colors of vegetables should be the frequent rotation, and the cooking time is shorter, as well as uses less oil and salt. In addition, you can eat dark vegetables: the micronutrient density of dark green, dark red, orange, purple vegetables is high, rich in carotene, also contains a variety of photochemical, not only stimulates the appetite, as well as has the effects of scavenging oxygen free radicals and oxidative damage and anti-tumor.

Moreover, you can eat vegetables of cruciferous and onion and garlic: cruciferous vegetables contain plant substances isothiocyanates; onion and garlic genus have sulfur compounds, and an important tumor suppressor components.

Cruciferous vegetables contain Chinese cabbage, seaweed, sprouts, red flower stalk etc.; cabbage such as broccoli, cauliflower, kale, broccoli, kohlrabi, etc.; mustard, such as leaf mustard, stem mustard, the root of mustard greens etc.; also have radish class.

Furthermore, you can also eat bacteria and algae food: mushrooms, white fungus, seaweed and other algae food are rich in plant polysaccharides; they have a role in anti-oxidation and the inhibition of iodine-rich sea algae, such as seaweed, kelp. And you can try to eat whole vegetables: vegetables nutritional value of different parts has a big difference. The mid-carotene, vitamin B2 and vitamin C content in the leaf are several times to ten times higher than the rhizome part of the same vegetables; the external dietary fiber content of vegetables is higher than that of flowering cabbage. Do not throw away the lettuce leaves, celery leaves, radish, aubergine, potato skins, lotus root, skin and other parts.

In addition, try to eat fresh vegetables: vegetables as much as possible to take advantage of the fresh to be edible, and now do now eat, and storing time should not be too long. If you want to save, you need to cold storage, to avoid too long, resulting in the loss of nutrients due to storage time. In addition, such as vegetables stored for too long may produce nitrite, the germination of potatoes can cause solanine and other harmful substances.

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INSIGHT: Hedge funds find ways to trade euro misery

BOSTON/NEW YORK (Reuters) - Two decades ago, George Soros rose to fame and fortune on his now-historic trade in which he took on the Bank of England and shrewdly wagered on a devaluation of the British pound.

But it's unlikely the current European monetary crisis and worries about Greece's potential exit from the euro zone will give rise to an investing legend like Soros, who made $1 billion in 1992 by betting on a decline in the price of the pound.

Instead, there are a multitude of strategies to play Europe's troubles, and many different participants, hedge fund managers say.

"There is not room for one player to have such impact," said John Brynjolfsson, whose California-based Armored Wolf hedge fund has been betting against the euro for quite some time. "Financial markets are so much bigger today."

A spokesman for Soros, who last year converted his Soros Fund Management to a family office and stopped managing money for outside investors, could not be reached for comment.

The euro zone crisis has gone on for so long it is difficult for investors to pinpoint an entry and exit point for a trading strategy. Positions and hedges require constant adjustment, making it difficult to come up with a single big-winning trade.

"It's unlikely in Europe, because the way Europe works is incremental crisis, incremental recovery," London-based Robert Marquardt, founder of fund of hedge funds firm Signet, said.

Brynjolfsson and several other U.S. money managers who are trying to profit from Europe's misery say they expect the current crisis to produce a lot of winners.

So far this year, the euro is down 3.3 percent against the U.S. dollar.

Money managers say it's hard to swing for the fences the way Soros did because institutional investors are far more squeamish about having too much money riding on any single trade.

There is also heightened sensitivity from pensions and endowments about taking up an investment strategy that might spark political outrage from European leaders.

Another thing working against the rise of a new Soros is that trading the euro zone, or even the fallout from a Greek exit, is much more complicated than betting against a single currency.

Money managers are trading the euro zone crisis by trading currencies, wagering on the direction of bank stocks or using derivatives like credit default swaps to bet on potential corporate and bank failures.

Greenlight Capital's David Einhorn recently said he is bullish on gold and gold miners, in part because of concern about the fallout from a euro zone meltdown.

Some managers are even going both short and long on different European sovereign debt, depending on their views of the financial stability of different countries.

Adam Fisher, manager of the $320 million Commonwealth Opportunity Capital hedge fund, noted that Soros faced a "single country, not 17 different countries, one decision maker, not 17."

Fisher's fund, which has more than 80 percent of its money invested in Europe, is taking a somewhat contrarian position by owning the European sovereign debt of Germany, the Netherlands, Italy and Spain.

TRADING GREECE'S EXIT

Hedge fund managers point out that given the up-and-down nature of the euro zone crisis, most hedge funds have been in and out of trades or forced to adjust positions depending on the changing political winds.

Earlier this year, for instance, it looked like concern about Greece exiting the euro had passed. But with the recent results of the Greek election at odds with the austerity measures demanded by its currency partners, the risk of a Greek departure from the euro zone has risen dramatically.

Recently, Fisher said his Los Angeles-based fund had reduced the size of some of its more bullish sovereign debt trades because he believes there will be "violent" market swings this summer.

"It is going to be incredibly difficult to manage risk through that environment," said Fisher, whose fund was up 8.8 percent through April. "I don't think hedging will do anything. The way you hedge, is you sell. You don't subtract risk by adding risk."

One way to profit from any greater swings in markets would be to play the spread between European and U.S. volatility indexes, Barclays Capital equity-linked strategists say. The European index should rise faster than the U.S. one.

Brynjolfsson, a former top portfolio manager for bond mutual fund firm Pacific Investment Management Co, is betting on Greece exiting the euro. He said it will be hard for European leaders to take the necessary steps to appease the Greek government without infuriating politicians in other euro zone countries.

"As the wheels began falling off the bus, we adjusted to have a short bias and that has worked out," said Brynjolfsson, whose $750 million hedge fund is up 2 percent this year, largely on its short bet against the euro.

Some managers are even preparing for the possibility other countries will exit the euro zone.

One such trade involves taking a long position in Italian government debt denominated in U.S. dollars, and a corresponding short position in the debt denominated in euros, one hedge fund investor familiar with the strategy said. The belief is that if Italy is forced out of the euro - or the threat of that possibility grows - the U.S. dollar denominated portion will outperform.

Axel Merk, president and chief executive officer of Merk Investments, an investment advisory firm that specializes in currencies, said the growing problems with Greece and the euro zone led him recently to dump all the euros in his $517 million Merk Hard Currency Fund, which is up 2.29 percent for the year.

Merk now favors the Singapore dollar, which has climbed 1.34 percent since January.

Ray Dalio's $120 billion Bridgewater Associates gained 23 percent in 2011 in part because of profits made from a series of European bets, said a person familiar with the Westport, Conn.-based fund, who declined to discuss specifics. In a recent interview with Barron's, Dalio said European banks "are now over-leveraged and can't expand their balance sheets" and European nations "don't have enough buyers of their debt."

Dalio may be the U.S. money manager who comes closest to rivaling the Soros of two decades ago. His hedge fund is the industry's largest and he is widely regarded as one of the most successful managers.

RELATIVE VALUE

Among the ways funds are playing the European turmoil, some are betting against the fortunes of Spanish and Italian banks instead of simply focusing on sovereign debt.

John Paulson, among others, bets against European sovereign debt as a way to hedge the overall portfolio of his Paulson & Co hedge fund firm.

Daniel Loeb's Third Point fund put on a long position in Portuguese sovereign bonds in the first quarter because the New York-based manager believed the nation is in better shape than others in the euro zone.

"Portugal's debt profile is more consistent with Italy's than Greece's, its banks are substantially healthier than Spain's, and its government has enacted more aggressive labor reforms and is more stable than regimes in both countries," Loeb wrote in a May 16 investors' letter seen by Reuters.

So-called relative value trading - which involves trying to profit from a mispricing between a pair of related securities - has proved popular in this crisis as managers refrain from directional bets, prime brokers and hedge funds say.

Firms such as Boaz Weinstein's New-York-based Saba Capital and Yan Huo's London-based Capula Investment Management are among the shrewdest names in the sector, with both funds performing well amid market turmoil.

"The thing about Europe is that everything you want to do is a relative value trade. A month from now Greece could be out of Europe, or everything could be OK, you just don't know, so you have to be on both sides of the trade," Signet's Marquardt said.

If nothing else, the European crisis is forcing managers to keep coming up with new strategies to trade. One might say it has almost become an incubator for hedge fund managers to stretch their investment acumen.

Merk said he might look again at Europe if the political and financial situation becomes clearer. But he would likely do it a bit differently.

"If there is clarity in the process again, then we will certainly look at Europe again," he said. "But not through Greek debt, but through German bills."

(Additional reporting by Vikram Subhedar and Nishant Kumar in Hong Kong and Tommy Wilkes in London; Editing by Matthew Goldstein, Jennifer Ablan, Martin Howell)

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Monday, 28 May 2012

3DS Mod - Home Based Business Financing Guidebook

Well, the good thing is there are many resources accessible to finance the house based business. Youll need to do some research to track down whats found in the location, nevertheless this guide will display you many regions to search to get the financing you desire for the house based business.

The Small Business Administration SBA is a superb area to change to for house based business financing. It doesnt make grants that the house based business wont need to pay back, nor does it create direct loans to little and house based companies. Instead, the SBA ensures loans provided by private creditors. This decreases the risk connected with new organization ventures and makes it simpler to get creditors for the house based business. However, to get a SBA loan, the house based business should be a profit generating 1, and you may need to guarantee the financing personally. This means putting the personal assets in danger. Additionally, to qualify for an SBA help and/or financing, the house based business must be inside the United States, and theres additional criteria that must be met. Still, if youre trying to find financial help to commence the house based business, the SBA is a good area to commence.

Private grants are another type of financing you can search into for the house based business. There are numerous different kinds of grants, and there might probably be 1 for the house based business. The Internet is a remarkable area to research before you buy. The grant procedure could take awhile, so if choose this might be the path you need to go for financing the house organization, and the house based business meets the criteria of a grant, you should get started with all the grant writing procedure as soon as possible. Also, you may should hire a grant writer to assist you. Grant requirements are strenuous, and theres a remarkable deal of competition for little and house based business grants. Its seriously worth the time and effort to research grants, though, to try to get a grant for the house based business because the income provided refuses to must be paid back.

Another type of house based business financing is through whats called angel investors. These are investors that are ready to lend income to new little and house based companies, generally because they know a superior thing whenever they view it and are prepared to take several risks. Angel investors for house based companies will not be that effortless to find, nevertheless with several networking inside your area, you can locate many. Joining the local Chamber of Commerce is a good option to find angel investors. Also, speak with accountants that can bring together many investors for the house based business. This happens a lot more often than you may realise because investing in a little or house based business could supply superior tax break for most people. And then there are just some good souls available who want to aid others commence house based companies because theyve been there themselves and managed to create successful house based companies inside own.

One final note. The only investors to be careful of for the house based business are those you could also find inside the own family. It just simply isnt a good idea to need income for the house based business, or for whatever else for that matter, from family. There are just so many items that can go incorrect inside a financial obligation like this. A relative you need income from to commence the house based business can pressure anyone to run the company their option, or worse, the house based business can go beneath and need to declare bankruptcy. Its horrible to get rid of any investors income, but when its Uncle Davids, its much worse. So only need income for the house based business from family as a last location, and only when youre certain you may have a certain thing.

Charles Fuchs

http://www.charlesfuchs.com

http://charlesfuchs.blogspot.com

I grant permission to create this short article, electronically or inside print, as prolonged as the bylines are included, with a live link, as well as the post is not changed by any means.

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Bud dumps heavy rain on Mexico?s Pacific coast

MANZANILLO, Mexico (Reuters) ? The remnants of the first hurricane of the 2012 season, Bud, dumped heavy rain along Mexico?s coast early on Saturday but caused little damage before it turned back into the Pacific.

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Sunday, 27 May 2012

Remodel California Homes Westchester CA 90045 - The SLC

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Also provide a home with added living space, home additions can be a terrific speculation. However, before venture on building a house totaling, or other large home remodel project, there are a number of main substance that should be considered first. These object include neighboring house advertise worth, residence addition expenses, architectural strategy, finances, timetable for completion, and your personal disruption threshold and sweat equity commitment level. Additional contractors specialize in original and second tale home additions and assembly your residence additional look as if it were constantly part of your original house. We are a professional home builders that surpass at resizing and expanding existing residence while maintain or increase the curb attract and inside usability. Our construction and remodeling knowledge way your new home adding or remodel plan will become out superior than you ever imagined. We are constantly looking for new products to advance your house plan. We are expert at power efficient solutions problem solving solutions normally connected with major home improvement, addition, renovation, expansion and extra. For qualified universal supplier work you can depend on, count on our contractors. We offer excellent remodel and renovations work, including residence maintenance and post-construction clean-up services. Our registered and certified contractors are the finest for their particular district. Whether you?re look for center or exterior work or want a small of equal, our team of professional is here to assist you choose which changes and upgrade are correct for you. We give restore, remodeling and structure service for residential and saleable possessions owner, include home additional, bathroom remodel, kitchen reconstruct, green renovation, energy effectiveness preparation and upgrading, floor, roofing, infraction corrections, among other service. From small maintenance to remodel your kitchen, your restroom, inner or exterior of your home or you need to design and plan the entire facilities for a society, our business is committed to exceed our cosumer outlook.

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GOP attacks 'Obama economy' in Memorial Day message

Rep. Lynn Jenkins (R-Kansas) pushed the Republican economic agenda in her party's address for Memorial Day weekend.

"On Memorial Day, as we consider the sacrifices our service members and their families have made, we are reminded to never squander the blessings of liberty," Jenkins said. "That is why helping to create jobs and grow our economy will continue to be Republicans' focus in the weeks and months ahead."

Jenkins, whose district includes multiple military bases, said "we owe it to our service members" to grow the economy.

"Unfortunately, roughly 22 million of our fellow citizens are struggling to find a good-paying full-time job in President Obama's economy," she said.

"The Republican jobs plan is built around small businesses, not big government, and instead of short-term 'stimulus,' our plan emphasizes long-term growth."

Jenkins said Obama "demonizes home grown energy" for not approving the Keystone XL pipeline, which would run through Kansas.

She also pushed for reducing government regulation on businesses, repealing the healthcare reform law and cutting spending.

"Through the Republican jobs plan, the House has voted to take these common-sense steps to sustained job growth and prosperity," she said.


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Increase Your Kid's Self-Esteem

Some people possess a sturdy viewpoint within the importance of self-esteem in kids. Some individuals possess an unfavorable opinion and think too much emphasis is placed on self-esteem today. Other?s think strongly that self-esteem improvement is crucial in kids.

The truth is the fact that there each events possess a share within the real truth. There is possibly an excessive amount of emphasis on self-esteem at this time and self-esteem improvement is critical. Even so middle floor may be found amongst the two teams. The emphasis should not be on constructing self-esteem but relatively assisting children find out and develop so that they normally develop a feeling of really worth and worth.

Self-esteem is really a big important to accomplishment in daily life. The improvement of the good self-concept or wholesome self-esteem is exceptionally click Here vital to the joy and achievement of kids.

Self-esteem is how we really feel about ourselves, and our habits clearly reflects these emotions. In case you child has higher self-esteem she is likely to act independently, presume duty, get pride in her accomplishments, tolerate aggravation, try new duties and challenges, manage good and unfavorable emotions, and present help to other individuals. In case your child has lower self-esteem he will prevent trying new things, feel unloved and undesirable, blame others for his own shortcomings, really feel (or pretend to feel) emotionally indifferent, be unable to tolerate a normal amount of aggravation, put down his own skills and abilities, and be very easily motivated.

Mothers and fathers have essentially the most affect on their child?s self-esteem. Most parents usually do not realize how excellent check here out an impact their phrases and steps have on their kid.

Be Speedy With Praise

After you feel very good about your kid, point out it to him. Dad and mom are normally rapid to precise negative feelings to young children but generally do not get around to describing constructive feelings. A child doesn?t know when you are experiencing good about him unless of course you inform him. He desires to hear you tell him which you like having him within the household. Young children bear in mind positive statements we say to them. They shop them up and ?replay? these statements to themselves. Make a stage of providing your child words of encouragement throughout every single day. Look for conditions where your child is undertaking a great job, working tough, trying a new challenge, conquering a trouble or exhibiting a talent.

Lay It On Thick

Be generous along with your praise. Use what exactly is referred to as descriptive praise as an alternative to the general, for example ?good job?. One example is, for the duration of a latest swimming lesson my son was expected to swim the length in the pool. He was frightened and did not believe he could allow it to be. When he effectively accomplished the aim I told him I used to be happy of him for two items. One for attempting even though he was frightened he?d fail and two for pushing himself to attain his goal.

Make Them Talk The Speak

Educate your kid to apply producing constructive self-statements. Psychologists have found that unfavorable self-talk is often the foundation lead to of melancholy and anxiousness. What we consider establishes how we feel about ourselves and individuals feelings determine how we behave. This can be the purpose it is critical to teach youngsters talk to on their own inside a constructive way. It is possible to get started them off by inquiring directed queries.

Stay clear of Title Calling

When it is actually often crucial for dad and mom to become important, the focus needs to be around the action you would prefer to see as an alternative to the child. Instead of calling a child a slob for retaining a messy space concentrate around the wanted action, that is to kind clothes and toys into their appropriate locations. Inspire the kid by declaring one thing like ?I know you can get this location ship shape by dinner? and reward them with specific praise ?You did an incredible work cleansing up your room?.

Generally Talk Of the Child Just as if They Had been Listening

Several mother and father do a wonderful job of creating up their kid?s self esteem when spending time with all the youngster. Then later on they undo all their fantastic perform and permit the youngster overhear some negative responses. It?s tough to explain away or undo this harm as you could well not even know when it occurs. Certainly dad and mom should communicate with each other about their children and adults typically should vent their frustrations. Just ensure when you do in order that your youngster will not be able to overhear. Even a youngster who?s evidently concentrating on play will perk his ears when he hears his title.

In case you stick to these five procedures then your child?s self worth will grow.

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Saturday, 26 May 2012

Server Web hosting Manual And kinds : calopus3742

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